Differential pattern of brain‐specific CSF proteins tau and amyloid‐beta in Parkinsonian syndromes
Identifieur interne : 001D48 ( Main/Exploration ); précédent : 001D47; suivant : 001D49Differential pattern of brain‐specific CSF proteins tau and amyloid‐beta in Parkinsonian syndromes
Auteurs : Sigurd D. Süssmuth [Allemagne] ; Ingo Uttner [Allemagne] ; Bernhard Landwehrmeyer [Allemagne] ; Elmar H. Pinkhardt [Allemagne] ; Johannes Brettschneider [Allemagne] ; Axel Petzold [Royaume-Uni] ; Bernd Kramer [Allemagne] ; Jörg B. Schulz [Allemagne] ; Christian Palm [Allemagne] ; Markus Otto [Allemagne] ; Albert C. Ludolph [Allemagne] ; Jan Kassubek [Allemagne] ; Hayrettin Tumani [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-07-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Amyloid, Amyloid beta-Peptides (cerebrospinal fluid), Cerebrospinal fluid, Encephalon, Female, Glial Fibrillary Acidic Protein (cerebrospinal fluid), Humans, Male, Middle Aged, Multiple system atrophy, Nervous system diseases, PSP‐P, Parkinson disease, Parkinsonian Disorders (cerebrospinal fluid), Peptide Fragments (cerebrospinal fluid), Richardson's syndrome, Statistics, Nonparametric, Supranuclear ophthalmoplegia, Tau protein, biomarker, cerebrospinal fluid, multiple system atrophy, progressive supranuclear palsy, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Amyloid beta-Peptides, Glial Fibrillary Acidic Protein, Peptide Fragments, tau Proteins.
- cerebrospinal fluid : Parkinsonian Disorders.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP‐Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid‐beta1–42 (Aβ1–42), Aβ1–40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP‐Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age‐matched controls (P ≤ 0.001). Ratios of P‐tau/T‐tau were significantly different in Parkinsonian syndromes. CSF Aβ1–42 was decreased only in patients with Richardson's syndrome. In a subset of Parkinsonian syndromes, we found elevated GFAP concentrations and increased CSF/serum albumin ratios. There were no correlations between biomarker concentrations and clinical scores in any of the diseases. In conclusion, this preliminary data show that changes in CSF tau and Aβ1–42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22895
Affiliations:
- Allemagne, Royaume-Uni
- Angleterre, Bade-Wurtemberg, Basse-Saxe, District de Tübingen, Grand Londres
- Göttingen, Londres, Ulm
- Université d'Ulm
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Pinkhardt</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Brettschneider, Johannes" sort="Brettschneider, Johannes" uniqKey="Brettschneider J" first="Johannes" last="Brettschneider">Johannes Brettschneider</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deparment of Neuroimmunology, Institute of Neurology, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kramer, Bernd" sort="Kramer, Bernd" uniqKey="Kramer B" first="Bernd" last="Kramer">Bernd Kramer</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegeneration and Restorative Research, Center for Neurological Medicine, University of Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Palm, Christian" sort="Palm, Christian" uniqKey="Palm C" first="Christian" last="Palm">Christian Palm</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Tumani, Hayrettin" sort="Tumani, Hayrettin" uniqKey="Tumani H" first="Hayrettin" last="Tumani">Hayrettin Tumani</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-15">2010-07-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1284">1284</biblScope><biblScope unit="page" to="1288">1288</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E06A7675ED6F9BC2A578724A87C6A31F18A5977C</idno><idno type="DOI">10.1002/mds.22895</idno><idno type="ArticleID">MDS22895</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Amyloid</term><term>Amyloid beta-Peptides (cerebrospinal fluid)</term><term>Cerebrospinal fluid</term><term>Encephalon</term><term>Female</term><term>Glial Fibrillary Acidic Protein (cerebrospinal fluid)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>PSP‐P</term><term>Parkinson disease</term><term>Parkinsonian Disorders (cerebrospinal fluid)</term><term>Peptide Fragments (cerebrospinal fluid)</term><term>Richardson's syndrome</term><term>Statistics, Nonparametric</term><term>Supranuclear ophthalmoplegia</term><term>Tau protein</term><term>biomarker</term><term>cerebrospinal fluid</term><term>multiple system atrophy</term><term>progressive supranuclear palsy</term><term>tau Proteins (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Amyloid beta-Peptides</term><term>Glial Fibrillary Acidic Protein</term><term>Peptide Fragments</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Amyloïde</term><term>Atrophie multisystématisée</term><term>Encéphale</term><term>Liquide céphalorachidien</term><term>Maladie de Parkinson</term><term>Ophtalmoplégie supranucléaire</term><term>Pathologie du système nerveux</term><term>Protéine tau</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP‐Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid‐beta1–42 (Aβ1–42), Aβ1–40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP‐Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age‐matched controls (P ≤ 0.001). Ratios of P‐tau/T‐tau were significantly different in Parkinsonian syndromes. CSF Aβ1–42 was decreased only in patients with Richardson's syndrome. In a subset of Parkinsonian syndromes, we found elevated GFAP concentrations and increased CSF/serum albumin ratios. There were no correlations between biomarker concentrations and clinical scores in any of the diseases. In conclusion, this preliminary data show that changes in CSF tau and Aβ1–42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>District de Tübingen</li><li>Grand Londres</li></region><settlement><li>Göttingen</li><li>Londres</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Sussmuth, Sigurd D" sort="Sussmuth, Sigurd D" uniqKey="Sussmuth S" first="Sigurd D." last="Süssmuth">Sigurd D. Süssmuth</name></region><name sortKey="Brettschneider, Johannes" sort="Brettschneider, Johannes" uniqKey="Brettschneider J" first="Johannes" last="Brettschneider">Johannes Brettschneider</name><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name><name sortKey="Kramer, Bernd" sort="Kramer, Bernd" uniqKey="Kramer B" first="Bernd" last="Kramer">Bernd Kramer</name><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name><name sortKey="Palm, Christian" sort="Palm, Christian" uniqKey="Palm C" first="Christian" last="Palm">Christian Palm</name><name sortKey="Pinkhardt, Elmar H" sort="Pinkhardt, Elmar H" uniqKey="Pinkhardt E" first="Elmar H." last="Pinkhardt">Elmar H. Pinkhardt</name><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B." last="Schulz">Jörg B. Schulz</name><name sortKey="Tumani, Hayrettin" sort="Tumani, Hayrettin" uniqKey="Tumani H" first="Hayrettin" last="Tumani">Hayrettin Tumani</name><name sortKey="Uttner, Ingo" sort="Uttner, Ingo" uniqKey="Uttner I" first="Ingo" last="Uttner">Ingo Uttner</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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